You sometimes just have to use JavaScript to designate specific resolutions, but the key is to create a fluid layout so it will look nearly the same in all resolutions, you can do this by using a background that repeats instead of a single, long image; you may have to use 3-piece elements or more for desirable background images that have a left, right and middle piece (the middle piece generally repeats). You can also often depend on percentages when specifying the width instead of pixels.
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