I can't think of any major differences at the moment, most designs I code I get the same results in Chrome as I do Firefox, there's sometimes slight differences, like the padding is greater or less in Chrome, but I never find anything too major. If you're using jQuery, here's how to designate webkit (namely, Chrome and Safari) for webkit-specific CSS issues:
Code:
<script type="text/javascript">
if ($.browser.webkit) {
$('body').addClass('webkit');
}
</script>
You can then use the webkit class to fix any issues you find in webkit.
Bookmarks