I'm old fashioned, I like to have a pointer show up when I mouse over a link and it doesn't when I move my mouse over Enter on your home page - as well as a few other areas on your site (like the arrows when I am viewing an image, or the View Comments when I am viewing an image). In some places (like Enter on the homepage) I guess it's no big deal because it's reasonably obvious, but in other places, you just don't know what is a link and what isn't.
Also, if I open a picture from, I can't close it (by either clicking on the X up in the top right or the X down in the information area), however, if I changed the picture by using the arrows, and then click on the X in the top right (but no the X in the information area) I can close it. Chrome v3.0
Also, if I view the first image in a series and click on the left arrow to see the previous image, it displays loading forever. Again, all this is in Chrome, but you should check it in other browsers and if it's the same, then the site, despite it's unique design, really isn't ready to be live.