If you mean open it up on the user's computer, then no, I don't think so, as that would be a horrible security hole. Now, if you can find some sort of Flash, Java, or JavaScript app that does what you need within the browser itself, you might be able to open the file in that, but not just arbitrarily open any program on the user's computer. :eek:
And if I'm misunderstanding what you're asking, we may need a few more details. (E.g.: PHP has image manipulation libraries for working with the image on the server side, such as the GD and ImageMagick extensions.)